Palmitoyl coenzyme A lithium

Names

[ Name ]:
Palmitoyl coenzyme A lithium

[Synonym ]:
Palmitoyl coenzyme A lithium salt
Palmitoyl coenzyme A lithium salt is also known as n-Hexadecanoyl Coenzyme A.
n-Hexadecanoyl Coenzyme A
Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxohexadecyl)thio]ethyl]amino]propyl]amino]butoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:1)
Hexadecanoyl coenzyme A
MFCD01863103

Biological Activity

[Description]:

Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Palmitoyl coenzyme A lithium (100 μM) reversibly inhibits acetyl coenzyme A carboxylase activity from chicken hepatocytes and is competitive with citric acid and has an important role in the regulation of fatty acid synthesis in vivo[1]. Palmitoyl coenzyme A lithium with a high levels in mitochondria reduces the entry of ADP, which leads to an increased inhibition of glutamate dehydrogenase by palmitoyl CoA[2].

[References]

[1]. A G Goodridge, et al. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 1972 Nov 10;247(21):6946-52.

[2]. L A Fahien, et al. Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys. 1981 Nov;212(1):247-53.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₆₅LiN₇O₁₇P₃S

[ Molecular Weight ]:
1011.876

[ Exact Mass ]:
1011.353027

[ Water Solubility ]:
Soluble in water

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.

Biochim. Biophys. Acta 1451 , 1, (1999)

Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and cellular proteins. This review will highlight the latest advances in our understanding of the enzymology of N-my...

Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.

Science 278 , 1132-1135, (1997)

Palmitoylation of the alpha subunit of the guanine nucleotide-binding protein Gz inhibited by more than 90 percent its response to the guanosine triphosphatase (GTPase)-accelerating activity of Gz GAP...