Bintrafusp alfa

Names

[ CAS No. ]:
1918149-01-5

[ Name ]:
Bintrafusp alfa

Biological Activity

[Description]:

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Bintrafusp alfa 可以赋予长期保护性免疫，降低调节性 T 细胞功能，显着增加 CD8+ T 细胞和自然杀伤细胞浸润，并减少肿瘤内骨髓来源的抑制细胞浸润[1]。

[References]

[1]. Strauss J, et, al. Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies. J Immunother Cancer. 2020 Dec;8(2):e001395.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds