APJ receptor agonist 6

Names

[ CAS No. ]:
1965244-85-2

[ Name ]:
APJ receptor agonist 6

Biological Activity

[Description]:

APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

EC50: 0.800 ± 0.1 μM (Apelin Receptor calcium), 0.844 ± 0.2 μM (Apelin Receptor cAMP), 6.22 ± 2.0 μM (Apelin Receptor β-arrestin), >10 μM (AT1 calcium)[1]


[References]

[1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H34FN3O5

[ Molecular Weight ]:
523.60

Related Compounds