APJ receptor agonist 7

Names

[ CAS No. ]:
2100850-28-8

[ Name ]:
APJ receptor agonist 7

Biological Activity

[Description]:

APJ receptor agonist 7 (compound 37) is a potent and orally active APJ (apelin receptor) agonist, with Ki of 0.059 μM. APJ receptor agonist 7 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

EC50: 0.063 ± 0.004 μM (Apelin Receptor β-arrestin), 0.070 ± 0.009 μM (Apelin Receptor calcium), 0.097 ± 0.032 μM (Apelin Receptor cAMP), >10 μM (AT1 calcium)[1]


[References]

[1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H46N4O4

[ Molecular Weight ]:
550.73

Related Compounds