1-(2-phenoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol,hydrochloride
Names
[ CAS No. ]:
21299-86-5
[ Name ]:
1-(2-phenoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol,hydrochloride
[Synonym ]:
Ph-QA 33
Chemical & Physical Properties
[ Boiling Point ]:
453.4ºC at 760 mmHg
[ Molecular Formula ]:
C18H24ClNO3
[ Molecular Weight ]:
337.84100
[ Flash Point ]:
228ºC
[ Exact Mass ]:
337.14400
[ PSA ]:
50.72000
[ LogP ]:
4.40950
[ Vapour Pressure ]:
5.18E-09mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB7560000
- CHEMICAL NAME :
- 2-Propanol, 1-(isopropylamino)-3-(o-phenoxyphenoxy)-, hydrochloride, (+-)-
- CAS REGISTRY NUMBER :
- 21299-86-5
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C18-H23-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 337.88
- WISWESSER LINE NOTATION :
- 1Y1&M1YQ1OR BOR &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 810 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 27,453,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Behavioral - food intake (animal)
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968