SN38-COOH

Names

[ CAS No. ]:
2170118-23-5

[ Name ]:
SN38-COOH

Biological Activity

[Description]:

SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Wilson Lim, et al. Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. PLoS Negl Trop Dis. 2018 Apr 26;12(4):e0006437.  

[2]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H24N2O8

[ Molecular Weight ]:
492.48

Related Compounds