tert-Butyl (35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)carbamate

Names

[ CAS No. ]:
2218463-36-4

[ Name ]:
tert-Butyl (35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)carbamate

[Synonym ]:
MFCD11041098

Biological Activity

[Description]:

N-Boc-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₅₉NO₁₄

[ Molecular Weight ]:
645.78