Glucocerebrosidase-IN-1

Names

[ CAS No. ]:
2279945-76-3

[ Name ]:
Glucocerebrosidase-IN-1

Biological Activity

[Description]:

Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[Target]

IC50: 29.3 ± 1.8 μM (Glucocerebrosidase)[1]


[In Vitro]

Glucocerebrosidase-IN-1 (compound 11a) is able to enhance GCase activity 1.8-fold in fibroblasts bearing the homozygous L444P mutation[1].

[References]

[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H27NO3

[ Molecular Weight ]:
245.36

Related Compounds