KRAS G12C inhibitor 16

Names

[ CAS No. ]:
2349392-79-4

[ Name ]:
KRAS G12C inhibitor 16

Biological Activity

[Description]:

KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:97 nM (IC50)


[References]

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21ClFN3O3

[ Molecular Weight ]:
453.89

Related Compounds