Fmoc-NH-PEG15-CH2CH2COOH

Names

[ CAS No. ]:
2378590-46-4

[ Name ]:
Fmoc-NH-PEG15-CH2CH2COOH

Biological Activity

[Description]:

Fmoc-NH-PEG15-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C48H77NO19

[ Molecular Weight ]:
972.12

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds