Isoallolithocholic acid-d2

Names

[ CAS No. ]:
2410277-69-7

[ Name ]:
Isoallolithocholic acid-d2

Biological Activity

[Description]:

Isoallolithocholic acid-d2 is the deuterium labeled Isoallolithocholic acid. Alloisolithocholic acid (AILCA) activates large-conductance calcium-activated potassium (BK) channels with an EC50 value of 44.21 μM in Xenopus oocytes[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Bukiya AN, et al. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels. J Lipid Res. 2008 Nov;49(11):2441-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H38D2O3

[ Molecular Weight ]:
378.58

Related Compounds