NS2B/NS3-IN-6

Names

[ CAS No. ]:
2459657-57-7

[ Name ]:
NS2B/NS3-IN-6

Biological Activity

[Description]:

NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 2.23 µM (ZIKV NS2B/NS3 protease), 25.2 µM (DENV NS2B/NS3 protease)[1]


[References]

[1]. Maus H, et al. SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases. Bioorg Med Chem. 2021 Oct 1;47:116392.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H19N3O5S2

[ Molecular Weight ]:
433.50

Related Compounds