ATX inhibitor 15

Names

[ CAS No. ]:
2484811-52-9

[ Name ]:
ATX inhibitor 15

Biological Activity

[Description]:

ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Target]

Autotaxin:2.17 nM (IC50)


[References]

[1]. Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H19F3N2O3

[ Molecular Weight ]:
380.36

Related Compounds