MIF-IN-6

Names

[ CAS No. ]:
2582758-61-8

[ Name ]:
MIF-IN-6

Biological Activity

[Description]:

MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

IC50: 1.4 μM (MIF)[1] Ki: 0.96 μM (MIF)[1]


[References]

[1]. Xiao Z, Fokkens M, Chen D, et al. Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF). Eur J Med Chem. 2020;186:111849.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H13ClFN5O2

[ Molecular Weight ]:
385.78

Related Compounds