(R)-TTBK1-IN-1

Names

[ CAS No. ]:
2735015-59-3

[ Name ]:
(R)-TTBK1-IN-1

Biological Activity

[Description]:

(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19N5O2

[ Molecular Weight ]:
337.38

Related Compounds