Anti-infective agent 4

Names

[ CAS No. ]:
2738381-52-5

[ Name ]:
Anti-infective agent 4

Biological Activity

[Description]:

Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 0.016 μM (Trypanosoma cruzi)[1]


[In Vitro]

Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.016 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: 3T3 cells Concentration: 0.1 nM-100 μM Incubation Time: 48 hours Result: Showed activity against 3T3 cells with an CC50 value of ＞37 μM.

[In Vivo]

Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg once daily for five days Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.

[References]

[1]. Ang CW, et al. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. J Med Chem. 2022 Sep 16.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H12F3N5O4

[ Molecular Weight ]:
431.32

Related Compounds