Antimalarial agent 16
Names
[ CAS No. ]:
2773408-33-4
[ Name ]:
Antimalarial agent 16
Biological Activity
[Description]:
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].
[Related Catalog]:
[Target]
IC50: 2.0 nM (P. falciparum)[1]
[In Vivo]
Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1]. Animal Model: Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1] Dosage: 40 or 200 mg/kg Administration: Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days Result: Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8. Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C30H32N2O6
[ Molecular Weight ]:
516.58