mHTT-IN-1

Names

[ CAS No. ]:
2839311-21-4

[ Name ]:
mHTT-IN-1

Biological Activity

[Description]:

mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Brom, et al. Preparation of thiazolopyrimidinone derivatives and uses thereof. World Intellectual Property Organization, WO2022194801 A1. 2022-09-22.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19N7OS

[ Molecular Weight ]:
381.45

Related Compounds