SF-1 antagonist-1

Names

[ CAS No. ]:
2842079-86-9

[ Name ]:
SF-1 antagonist-1

Biological Activity

[Description]:

SF-1 antagonist-1 (compound 11) is a antagonist of steroidogenic factor 1 (SF-1). SF-1 antagonist-1 affects SF-1 transcriptional activity with an EC50 value of ＜200 nM. SF-1 antagonist-1 inhibits the proliferation of Rat Leydig tumor cells. SF-1 antagonist-1 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

SF-1 antagonist-1 (0-20 μM) affects SF-1 transcriptional activity with an EC50 value of ＜200 nM[1]. SF-1 antagonist-1 (0-20 μM; 48 h) affects proliferation of R2C cells[1]. Cell Proliferation Assay[1] Cell Line: Rat Leydig tumor cell line, R2C Concentration: 0-20 μM Incubation Time: 48 h Result: Inhibited proliferation of R2C cells with an EC50 value of ＜200 nM.

[References]

[1]. Raheja Neil, et al. PYRAZOLOPYRIMIDINONE COMPOUNDS. WO2022204481. 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18F4N6O3

[ Molecular Weight ]:
490.41

Related Compounds