Epoprostenol

Names

[ Name ]:
Epoprostenol

[Synonym ]:
PGX
Epoprostenol
MFCD00135629
Prostaglandin l2
prostacyclin
Vasocyclin
PGl2
ProstaglandinI
PGX(prostaglandin)
Cyclo-Prostin
EINECS 263-273-7
Prostaglandin X

Biological Activity

[Description]:

Epoprostenol (Prostaglandin I2), the synthetic form of the natural prostaglandin derivative Prostacyclin (Prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH. Epoprostenol is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Provencher S, et al.Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterialhypertension. PLoS One. 2015 Mar 20;10(3):e0120657.

Chemical & Physical Properties

[ Density]:
1.221g/cm3

[ Boiling Point ]:
530.2ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₃₁NaO₅

[ Molecular Weight ]:
374.44700

[ Flash Point ]:
182.1ºC

[ Exact Mass ]:
374.20700

[ PSA ]:
89.82000

[ LogP ]:
2.07380

[ Index of Refraction ]:
1.611

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8008500

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-

CAS REGISTRY NUMBER :: 35121-78-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H32-O5

MOLECULAR WEIGHT :: 352.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 33,193,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 800 ng/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Maternal Effects - other effects

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 94,279,1992

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22;S26;S36