GP4G

Names

[ CAS No. ]:
4130-19-2

[ Name ]:
GP4G

[Synonym ]:
P(1),P(4)-bis(5'-guanosyl) tetraphosphate
[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
Bis(5'-guanosyl) tetraphosphate
P1,P4-Bis(5'-guanosyl) tetraphosphate
guanosine(5')tetraphospho(5')guanosine
GP4G
bis(guanylyl) diphosphate
(ppG)2
GppppG
G(5')p4(5')G
Diguanosine tetraphosphate

Biological Activity

[Description]:

GP4G (Diguanoside tetraphosphate) is a symmetrical bis-diphospho nucleoside that can be isolated from the cysts of Artemia salina. GP4G is an epithelial cell and hair growth regulator[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite


[In Vitro]

GP4G 可进入 Hela 和成纤维细胞，以双曲线饱和轮廓诱导 Hela 和成纤维细胞存活率的增加[1]。

[In Vivo]

GP4G (约1 mL，外用于背侧区域，每天一次，持续28天)有利于 Wistar 大鼠的毛发生长[1]。 Animal Model: Wistar rats (n = 5)[1] Dosage: About 1 mL of the product was applied daily with a cotton swab over a period of 28 days. Administration: Topically applied to the dorsal region (8 cm2, shaved), daily with a cotton swab over a period of 28 days. Result: Favored hair growth.

[References]

[1]. Te Velthuis AJ, et al. Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nat Rev Microbiol. 2016 Aug;14(8):479-93.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H28N10O21P4

[ Molecular Weight ]:
868.38600

[ Exact Mass ]:
868.03800

[ PSA ]:
515.13000

Precursor & DownStream

Precursor

DownStream

Related Compounds