5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one
Names
[ CAS No. ]:
4755-59-3
[ Name ]:
5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one
[Synonym ]:
Clodazone
Clodazone [INN-French]
5-chloro-1-(3-dimethylamino-propyl)-3-phenyl-1,3-dihydro-benzoimidazol-2-one
Clodazon [INN]
CLODAZON
2-Benzimidazolinone,5-chloro-1-(3-(dimethylamino)propyl)-3-phenyl
Clodazona [INN-Spanish]
5-Chloro-1-(3-(dimethylamino)propyl)-3-phenyl-2-benzimidazolinone
Clodazonum [INN-Latin]
Chemical & Physical Properties
[ Density]:
1.232g/cm3
[ Boiling Point ]:
466.3ºC at 760mmHg
[ Molecular Formula ]:
C18H20ClN3O
[ Molecular Weight ]:
329.82400
[ Flash Point ]:
235.8ºC
[ Exact Mass ]:
329.12900
[ PSA ]:
30.17000
[ LogP ]:
3.39730
[ Index of Refraction ]:
1.609
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE1800000
- CHEMICAL NAME :
- 2-Benzimidazolinone, 5-chloro-1-(3-(dimethylamino)propyl)-3-phenyl-
- CAS REGISTRY NUMBER :
- 4755-59-3
- BEILSTEIN REFERENCE NO. :
- 0894387
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C18-H20-Cl-N3-O
- MOLECULAR WEIGHT :
- 329.86
- WISWESSER LINE NOTATION :
- T6MTJ DXQR&R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 142 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 77 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 715 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 505 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- INPHB6 International Pharmacopsychiatry. (Basel, Switzerland) V.1-17, 1968-72. Volume(issue)/page/year: 1,214,1968