7-aminonitrazepam

Names

[ Name ]:
7-aminonitrazepam

[Synonym ]:
7-Amino-1,2-dihydro-3H-1,4-benzodiazepin-2-one
7-Amino-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin
7-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Amino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo<e>-1,4-diazepin
7-amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
7-Amino Nitrazepam
Ro 5-3072
7-Amino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl
7-amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepinon-(2)
7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
495.8ºC at 760 mmHg

[ Melting Point ]:
242-244ºC

[ Molecular Formula ]:
C₁₅H₁₃N₃O

[ Molecular Weight ]:
251.28300

[ Flash Point ]:
253.6ºC

[ Exact Mass ]:
251.10600

[ PSA ]:
67.48000

[ LogP ]:
2.21310

[ Index of Refraction ]:
1.683

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE9750000

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 7-amino-1,3-dihydro-5-phenyl-

CAS REGISTRY NUMBER :: 4928-02-3

BEILSTEIN REFERENCE NO. :: 0535813

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H13-N3-O

MOLECULAR WEIGHT :: 251.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,209,1991

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H332-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-36/37

[ RIDADR ]:
UN 1648 3 / PGII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay.

Ann. Clin. Biochem. 47(Pt 2) , 111-7, (2010)

Liquid chromatography linked to tandem mass spectrometry (LC/MS/MS) provides the ability to identify a range of benzodiazepines in accordance with European Union criteria and is an attractive method f...

A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry.

Biomed. Chromatogr. 23(7) , 740-4, (2009)

A highly sensitive method has been developed for the determination of urinary 7-aminonitrazepam (7-ANZP), the major metabolite of nitrazepam, using high-performance electrospray liquid chromatography ...

Determination of nitrazepam and its main metabolites in urine by thin-layer chromatography and direct densitometry.

J. Chromatogr. A. 339(1) , 163-9, (1985)

A method for the direct quantitative densitometry of nitrazepam and its main metabolites (7-aminonitrazepam, 7-acetamidonitrazepam and 2-amino-5-nitrobenzophenone) in urine was developed. The unchange...