75277-39-3

75277-39-3 structure

Name: HEPES sodium salt
Chemical Name: sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
CAS Number: 75277-39-3
Molecular Formula: C₈H₁₇N₂NaO₄S
Molecular Weight: 260.286
Catalog: Research Areas Others
Create Date: 2019-01-01 12:21:31
Modify Date: 2024-01-03 00:05:53
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3].

Name	sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
Synonyms	1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) HEPES sodium salt EINECS 278-169-7 Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate MFCD00036463 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt

Description	HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	HEPES maintains superhydrophilicity of titanium for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity[1]. HEPES drives lysosome biogenesis, affects MiT/TFE cytoplasmic-nuclear distribution, disrupts global cellular transcriptional profiles, resulting the activation of a MiT/TFE-dependent lysosomal-autophagic gene network in cultured RAW264.7 cells[3].
References	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. https://pubmed.ncbi.nlm.nih.gov/20631430/

Melting Point	234ºC
Molecular Formula	C₈H₁₇N₂NaO₄S
Molecular Weight	260.286
Exact Mass	260.080658
PSA	92.29000
Storage condition	Store at RT.
Stability	Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29335995

Precursor 2
103-76-4 1562-00-1
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%