155730-92-0
155730-92-0 structure
- Name: S-2E
- Chemical Name: 4-[[(3S)-1-(4-tert-butylphenyl)-5-oxopyrrolidin-3-yl]methoxy]benzoic acid
- CAS Number: 155730-92-0
- Molecular Formula: C22H25NO4
- Molecular Weight: 367.43800
- Create Date: 2016-12-01 19:02:41
- Modify Date: 2024-01-06 17:14:04
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S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research[1][2].
| Name | 4-[[(3S)-1-(4-tert-butylphenyl)-5-oxopyrrolidin-3-yl]methoxy]benzoic acid |
|---|---|
| Synonyms |
S-2E
(S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid |
| Description | S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research[1][2]. |
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| Related Catalog | |
| In Vivo | In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibits the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at Ki=18.11 μM and Ki=69.2 μM, respectively[1]. S-2E (3-30 mg/kg) given orally suppresses the secretion rate of very-low-density lipoprotein (VLDL)-cholesterol and triglyceride in Triton WR-1339-injected rats. Furthermore, S-2E lowers the blood total cholesterol and triglyceride levels simultaneously in Zucker fatty rats[1]. |
| References |
| Density | 1.189g/cm3 |
|---|---|
| Boiling Point | 599.089ºC at 760 mmHg |
| Molecular Formula | C22H25NO4 |
| Molecular Weight | 367.43800 |
| Flash Point | 316.118ºC |
| Exact Mass | 367.17800 |
| PSA | 66.84000 |
| LogP | 4.17920 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.58 |
| Storage condition | 20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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~78%
155730-92-0 |
| Literature: Ohno, Tomoyasu; Yano, Shin-Go; Yamada, Haruo; Shirasaka, Tetsuhiko; Yamamoto, Akira; Kobayashi, Kimiko; Ogawa, Kazuo Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1549 - 1554 |
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~%
155730-92-0 |
| Literature: Ohno, Tomoyasu; Yano, Shin-Go; Yamada, Haruo; Shirasaka, Tetsuhiko; Yamamoto, Akira; Kobayashi, Kimiko; Ogawa, Kazuo Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1549 - 1554 |
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~%
155730-92-0 |
| Literature: Ohno, Tomoyasu; Yano, Shin-Go; Yamada, Haruo; Shirasaka, Tetsuhiko; Yamamoto, Akira; Kobayashi, Kimiko; Ogawa, Kazuo Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1549 - 1554 |
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~%
155730-92-0 |
| Literature: Ohno, Tomoyasu; Yano, Shin-Go; Yamada, Haruo; Shirasaka, Tetsuhiko; Yamamoto, Akira; Kobayashi, Kimiko; Ogawa, Kazuo Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1549 - 1554 |
| Precursor 1 | |
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| DownStream 0 | |