137275-80-0

137275-80-0 structure

Name: Osemozotan hydrochloride
Chemical Name: 3-(1,3-Benzodioxol-5-yloxy)-N-[(2S)-2,3-dihydro-1,4-benzodioxin-2 -ylmethyl]-1-propanamine hydrochloride (1:1)
CAS Number: 137275-80-0
Molecular Formula: C₁₉H₂₂ClNO₅
Molecular Weight: 379.83500
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-11-16 20:35:51
Modify Date: 2024-01-13 15:42:43
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].

Name	3-(1,3-Benzodioxol-5-yloxy)-N-[(2S)-2,3-dihydro-1,4-benzodioxin-2 -ylmethyl]-1-propanamine hydrochloride (1:1)

Description	Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1]. Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2]. Animal Model: Female CD-1 mice with picrotoxin-induced decrease in female preference[1] Dosage: 1 mg/kg Administration: Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment Result: Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone. Animal Model: ICR mice with MAMP injection[2] Dosage: 1 mg/kg Administration: Intraperitoneal injection; 1 mg/kg; once Result: Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
References	[1]. Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. [2]. Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31.

Boiling Point	491.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₂ClNO₅
Molecular Weight	379.83500
Flash Point	203.8ºC
Exact Mass	379.11900
PSA	58.18000
LogP	3.80670
Vapour Pressure	8.32E-10mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF4731250

CHEMICAL NAME :: 1,4-Benzodioxin-2-methanamine, 2,3-dihydro-N-(3-(1,3-benzodioxol-5-yloxy)propyl)-, hydrochloride, (S)-

CAS REGISTRY NUMBER :: 137275-80-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H21-N-O5.Cl-H

MOLECULAR WEIGHT :: 379.87

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5168099

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