6271-21-2

6271-21-2 structure

Name: Dihydrolycorine
Chemical Name: α-dihydrolycorine
CAS Number: 6271-21-2
Molecular Formula: C₁₆H₁₉NO₄
Molecular Weight: 289.326
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-20 08:00:00
Modify Date: 2024-01-08 18:24:14
Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities[1]. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[2].

Name	α-dihydrolycorine
Synonyms	(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol Dihydrolycorine 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)- ihydrolycorine

Description	Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities[1]. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Protein synthesis[2]
In Vivo	Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion[1]. Dihydrolycorine inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively[3].
References	[1]. JIANG Shi-qin, et al. Therapeutic Effects of Dihydrolycorine on Focal Cerebral Ischemia-reperfusion Injury in Rats. 《Journal of Yunyang Medical College》 2009-05 [2]. Jimenez A, et al. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids. Biochim Biophys Acta. 1976 Mar 17;425(3):342-8. [3]. Chen BY, et al. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.