6453-67-4
6453-67-4 structure
- Name: Methyl pyropheophorbide-a
- Chemical Name: Pyropheophorbide-a methyl ester
- CAS Number: 6453-67-4
- Molecular Formula: C34H36N4O3
- Molecular Weight: 548.675
- Catalog: Signaling Pathways Others Others
- Create Date: 2018-09-26 14:32:55
- Modify Date: 2024-01-14 07:16:04
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Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, and is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].
| Name | Pyropheophorbide-a methyl ester |
|---|---|
| Synonyms |
3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-24,25-dihydro-4,8,13,18-tetramethyl-20-oxo-, methyl ester
Methyl pyrophaeophorbide a 9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoi Methyl 3-(14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-24,25-dihydro-3-phorbinyl)propanoate MPP A PYROPHEOPHORBIDE A METHYL ESTER MFCD00057989 Methyl pyropheophorbide a Methyl-13-decarboxy-methyl phaeophorbide-a 9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoicacid meth Pyropheophorbide-alpha methyl ester Methyl carbamic pyrophyllate a |
| Description | Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, and is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2]. Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells[1]. Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1]. Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1]. Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2]. Apoptosis Analysis[1] Cell Line: PC-3M cells Concentration: 2 μM Incubation Time: 12 h Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2). |
| In Vivo | Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice[2]. Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2] Dosage: 15 mg/kg Administration: Tail vein injection and topical injection Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 924.1±65.0 °C at 760 mmHg |
| Molecular Formula | C34H36N4O3 |
| Molecular Weight | 548.675 |
| Flash Point | 512.7±34.3 °C |
| Exact Mass | 548.278748 |
| PSA | 99.67000 |
| LogP | 6.95 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.642 |
| Storage condition | -20°C |