443683-76-9

443683-76-9 structure

Name: Alisol F 24-acetate
Chemical Name: Alisol F 24-acetate
CAS Number: 443683-76-9
Molecular Formula: C₃₂H₅₀O₆
Molecular Weight: 530.736
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2018-06-29 10:17:05
Modify Date: 2024-01-03 17:44:51
Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2].

Name	Alisol F 24-acetate
Synonyms	(8alpha,9beta,11beta,14beta,23S,24R)-24-(Acetyloxy)-16,23-epoxy-11,25-dihydroxy-dammar-13(17)-en-3-one Dammar-13(17)-en-3-one, 24-(acetyloxy)-16,23-epoxy-11,25-dihydroxy-, (8α,9β,11β,14β,16β,23S,24S)- (8α,9β,11β,14β,16β,23S,24S)-11,25-Dihydroxy-3-oxo-16,23-epoxydammar-13(17)-en-24-yl acetate

Description	Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	Alisol F 24-acetate (5、10 和 20 µM；24 h) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素 (Doxorubicin，HY-15142A) 的化学敏感性[2]。 Alisol F 24-acetate (5、10 和 20 µM) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素的积累。Alisol F 24-acetate (10 µM) 在 Caco-2 细胞单层中增加了地高辛 (Digoxin，HY-B1049) 的吸收 (AP-BL)，降低了地高辛的分泌 (BL-AP)[2]。 Cell Viability Assay[2] Cell Line: Caco-2 cells and MCF-7/DOX cells. Concentration: 1, 2, 5, 10, 20, 50 and 100 µM. Incubation Time: 24 h. Result: Significantly inhibited the cell viability (100 µM). Apoptosis Analysis[2] Cell Line: MCF-7/DOX cells. Concentration: 5, 10 and 20 µM. Incubation Time: 0.5, 1, 2, 3 and 4 h. Result: Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.
References	[1]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72(10):951-4. [2]. Pan G, et al. Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. Molecules. 2016 Feb 4;21(2):183.

Density	1.2±0.1 g/cm3
Boiling Point	634.3±55.0 °C at 760 mmHg
Molecular Formula	C₃₂H₅₀O₆
Molecular Weight	530.736
Flash Point	195.8±25.0 °C
Exact Mass	530.360718
LogP	4.54
Vapour Pressure	0.0±4.2 mmHg at 25°C
Index of Refraction	1.552

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