2410-60-8

2410-60-8 structure

Name: 18-Oxocortisol
Chemical Name: 17α-Hydroxy-aldosteron
CAS Number: 2410-60-8
Molecular Formula: C₂₁H₂₈O₆
Molecular Weight: 376.44300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Mineralocorticoid Receptor
Create Date: 2018-06-15 05:27:51
Modify Date: 2024-01-03 06:17:47
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

Name	17α-Hydroxy-aldosteron
Synonyms	(R)-11,17-Dihydroxy-17-(2-hydroxy-acetyl)-10-methyl-3-oxo-1,2,3,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-13-carbaldehyde

Description	18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor
In Vivo	Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].
References	[1]. Nakamura Y, et al. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primaryaldosteronism. J Clin Endocrinol Metab. 2011 Aug;96(8):E1272-8. [2]. Ulick S, et al. 18-oxocortisol, a naturally occurring mineralocorticoid agonist. Endocrinology. 1983 Dec;113(6):2320-2.