1219810-16-8

1219810-16-8 structure

Name: RSL3
Chemical Name: Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
CAS Number: 1219810-16-8
Molecular Formula: C₂₃H₂₁ClN₂O₅
Molecular Weight: 440.876
Catalog: Research Areas Cancer
Create Date: 2018-02-12 14:41:54
Modify Date: 2024-01-08 12:59:34
RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.

Name	Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
Synonyms	1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)- Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate RSL3 RSL3 (1S,3R-)

Description	RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.
Related Catalog	Research Areas >> Cancer
References	[1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.Front Oncol. 2015, 5: 131. [2]. Michel Weiwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826. [3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.