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1352792-74-5

1352792-74-5 structure
1352792-74-5 structure
  • Name: Verinurad
  • Chemical Name: Verinurad
  • CAS Number: 1352792-74-5
  • Molecular Formula: C20H16N2O2S
  • Molecular Weight: 348.418
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel URAT1
  • Create Date: 2018-08-01 15:20:24
  • Modify Date: 2024-01-31 20:09:55
  • Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC50 of 25 nM[1].

Name Verinurad
Synonyms Verinurad
2-{[3-(4-Cyano-1-naphthyl)-4-pyridinyl]sulfanyl}-2-methylpropanoic acid
RDEA3170
UNII:12WJ62D047
Propanoic acid, 2-[[3-(4-cyano-1-naphthalenyl)-4-pyridinyl]thio]-2-methyl-
Description Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC50 of 25 nM[1].
Related Catalog
Target

IC50: 25 nM (URAT1)[1]

In Vitro Verinurad inhibits the transport activity of human URAT1 in a dose-dependent manner, at high potency with an IC50 of 25 nM [1].
References

[1]. Tan PK, et al. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout. Sci Rep. 2017 Apr 6;7(1):665.

Density 1.3±0.1 g/cm3
Boiling Point 566.7±50.0 °C at 760 mmHg
Molecular Formula C20H16N2O2S
Molecular Weight 348.418
Flash Point 296.5±30.1 °C
Exact Mass 348.093262
LogP 3.77
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.692
Storage condition -20℃