1384984-18-2

1384984-18-2 structure

Name: VXc-486
Chemical Name: VXc-486
CAS Number: 1384984-18-2
Molecular Formula: C₂₁H₂₅FN₆O₃
Molecular Weight: 428.460
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-03 19:54:51
VXc-486 is a gyrase B inhibitor, with bactericidal activity. VXc-486 potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively[1].

Name	VXc-486
Synonyms	Urea, N-ethyl-N'-[6-fluoro-5-[2-(1-hydroxy-1-methylethyl)-5-pyrimidinyl]-7-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl]- 1-Ethyl-3-{5-fluoro-6-[2-(2-hydroxy-2-propanyl)-5-pyrimidinyl]-4-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl}urea

Description	VXc-486 is a gyrase B inhibitor, with bactericidal activity. VXc-486 potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	gyrase B[1]
References	[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.