1610954-97-6

1610954-97-6 structure

Name: LX2761
Chemical Name: LX-2761
CAS Number: 1610954-97-6
Molecular Formula: C₃₂H₄₇N₃O₆S
Molecular Weight: 601.31
Catalog: Signaling Pathways Membrane Transporter/Ion Channel SGLT
Create Date: 2018-01-16 23:25:40
Modify Date: 2024-01-03 16:06:32
LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1].

Name	LX-2761

Description	LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT
Target	IC50: 2.2 nM (hSGLT1), 2.7nM (hSGLT2)[1]
References	[1]. Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721.

Molecular Formula	C₃₂H₄₇N₃O₆S
Molecular Weight	601.31