858128-57-1

858128-57-1 structure

Name: SPB
Chemical Name: SPB
CAS Number: 858128-57-1
Molecular Formula: C₁₉H₁₅NO₈
Molecular Weight: 385.32
Catalog: Research Areas Others
Create Date: 2018-05-18 19:07:14
Modify Date: 2024-01-11 20:21:44
SPB is a key component of pulmonary surfactant, essential for normal lung function.

Name	SPB

Description	SPB is a key component of pulmonary surfactant, essential for normal lung function.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vivo	Human SP-B gene but not mouse SP-B is expressed in the lung of hTG SP-B-C and SP-B-T mice. For infected SP-B-C mice, the levels of bioluminescence increase rapidly from 0 to 24h after infection, remains high between 24 and 32 h, and then decreases; the bioluminescence levels are significantly lower (p<0.01) in the CMC2.24 treated group from 24 to 48 h after infection. In infected SP-B-T mice, the peak time of bioluminescence is at 12 h after infection, then the level decreases slowly. Lung tissues from of infected SP-B-C mice showed more apoptotic cells compared to infected SP-B-T mice. CMC2.24 treated SP-B-C and SP-B-T mice have decreased MMP-2, -9, and -12 activities compared to their respective untreated groups[1].
References	[1]. Xu Y, et al. DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN. Shock. 2016 Apr;45(4):375-84.