359436-59-2

359436-59-2 structure

Name: Mal-C2-cyclohexylcarboxyl-hydrazide TFA
Chemical Name: 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarbohydrazide trifluoroacetate (1:1)
CAS Number: 359436-59-2
Molecular Formula: C₁₄H₁₈F₃N₃O₅
Molecular Weight: 365.305
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-26 23:13:39
Modify Date: 2024-01-08 16:24:33
Mal-C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarbohydrazide trifluoroacetate (1:1)
Synonyms	MFCD01863409 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarbohydrazide trifluoroacetate (1:1)

Description	Mal-C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562