- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Isoprocurcumenol
- Price:
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Isoprocurcumenol
- Price: ￥3600.0/5mg
- Purity: 97.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Isoprocurcumenol
- Price: ￥2748.0/5mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Isoprocurcumenol
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
102130-90-5
102130-90-5 structure
- Name: Isoprocurcumenol
- Chemical Name: iso-Procurcumenol
- CAS Number: 102130-90-5
- Molecular Formula: C15H22O2
- Molecular Weight: 234.334
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2018-07-14 08:54:56
- Modify Date: 2024-01-16 15:42:56
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Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and Akt. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].
| Name | iso-Procurcumenol |
|---|---|
| Synonyms |
(1S,3aR,8aS)-1-Hydroxy-7-isopropylidene-1-methyl-4-methyleneoctahydro-6(1H)-azulenone
iso-Procurcumenol 6(1H)-Azulenone, octahydro-1-hydroxy-1-methyl-4-methylene-7-(1-methylethylidene)-, (1S,3aR,8aS)- Isoprocurcumenol |
| Description | Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and Akt. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
ERK Akt |
| In Vitro | Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化[3]。 Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖[3]。 Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1[ 3]。 Isoprocurcumenol 诱导细胞恢复和伤口愈合[3]。 Western Blot Analysis[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 10 μM Incubation Time: 10, 30, or 60 min Result: Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h. Cell Proliferation Assay[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM Incubation Time: 24 or 48 h Result: Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM. RT-PCR[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 1 μM Incubation Time: 1 h Result: Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1. |
| References |
[1]. Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 360.3±41.0 °C at 760 mmHg |
| Melting Point | 99.5-100.5 ºC (hexane ) |
| Molecular Formula | C15H22O2 |
| Molecular Weight | 234.334 |
| Flash Point | 153.7±20.2 °C |
| Exact Mass | 234.161987 |
| LogP | 2.59 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.523 |
| Water Solubility | Very slightly soluble (0.82 g/L) (25 ºC) |