132152-57-9

132152-57-9 structure

Name: Epi-Cryptoacetalide
Chemical Name: Epi-Cryptoacetalide
CAS Number: 132152-57-9
Molecular Formula: C₁₈H₂₂O₃
Molecular Weight: 286.366
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-10-16 10:52:16
Modify Date: 2024-01-24 17:35:20
Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities[1].

Name	Epi-Cryptoacetalide
Synonyms	Spiro[furan-2(3H),3'(1'H)-naphtho[1,2-c]furan]-1'-one, 4,5,6',7',8',9'-hexahydro-4,6',6'-trimethyl-, (2R,4R)- (2R,4R)-4,6',6'-Trimethyl-4,5,6',7',8',9'-hexahydro-1'H,3H-spiro[furan-2,3'-naphtho[1,2-c]furan]-1'-one

Description	Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	Ki: 0.3 μM (ER-α) and 1.92 μM (EP2 subtype)[1]
In Vitro	Epi-cryptoacetalide 是丹参中的一种成分，具有散瘀止痛、活血通经、除烦等功效；月经不调，经闭，痛经，脘腹作痛，胸腹刺痛，热痹，疮疡疮毒，失眠，肝脾肿痛，心绞痛。
References	[1]. Herbert Situmorang, et al. IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor. Ann Med Surg (Lond). 2021 Jun 17;67:102459.