1332329-27-7

1332329-27-7 structure

Name: Debio 0617B
Chemical Name: Debio 0617B
CAS Number: 1332329-27-7
Molecular Formula: C₂₈H₂₃ClF₃N₇O₂
Molecular Weight: 581.976
Create Date: 2018-07-20 04:02:14
Modify Date: 2024-01-10 19:18:44
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].

Name	Debio 0617B
Synonyms	N-{4-Chloro-3-[2-{[4-(methylcarbamoyl)phenyl]amino}-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]phenyl}-4-(trifluoromethyl)-2-pyridinecarboxamide MFCD30749186 2-Pyridinecarboxamide, N-[4-chloro-3-[7,8-dihydro-2-[[4-[(methylamino)carbonyl]phenyl]amino]pyrido[4,3-d]pyrimidin-6(5H)-yl]phenyl]-4-(trifluoromethyl)-

Description	Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
References	[1]. Maximilien Murone, et al. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34⁺ Stem/Progenitor Cells. Mol Cancer Ther. 2017 Aug;16(8):1497-1510.