71138-97-1

71138-97-1 structure

Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)
Chemical Name: HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE
CAS Number: 71138-97-1
Molecular Formula: C₁₀H₂₂O₉
Molecular Weight: 286.28
Catalog: Research Areas Others
Create Date: 2019-01-07 16:47:25
Modify Date: 2024-01-07 19:04:57
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].

Name	HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE

Description	Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].
Related Catalog	Research Areas >> Others
In Vivo	Hydroxypropylmethyl cellulose acetate succinate（2.5 g/kg；p.o.；单剂量）在大鼠无显著急性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（0.63、1.25、2.5 g/kg；p.o.；每日一次，连续 2 个月，每周 6 天）在大鼠无显著亚慢性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate（1.25 g/kg、2.5 g/kg；口服；每天一次，连续 2 个月，每周 6 天）在大鼠无显著慢性毒性[1]。
References	[1]. Hoshi N, et al. Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.

Molecular Formula	C₁₀H₂₂O₉
Molecular Weight	286.28