890655-80-8

890655-80-8 structure

Name: Verdiperstat
Chemical Name: Verdiperstat
CAS Number: 890655-80-8
Molecular Formula: C₁₁H₁₅N₃O₂S
Molecular Weight: 253.32
Catalog: Research Areas Neurological Disease
Create Date: 2019-02-09 18:23:02
Modify Date: 2024-01-11 21:11:28
Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

Name	Verdiperstat
Synonyms	MFCD30533444

Description	Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 630 nM (Myeloperoxidase)[1]
In Vitro	Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders[1]. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation[2].
References	[1]. Johnström P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. [2]. Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.