2158197-70-5

2158197-70-5 structure

Name: HS-1371
Chemical Name: HS-1371
CAS Number: 2158197-70-5
Molecular Formula: C₂₄H₂₄N₄O
Molecular Weight: 384.47
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2019-03-03 23:54:05
Modify Date: 2024-01-19 20:21:59
HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8 nM[1].

Name	HS-1371

Description	HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8 nM[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Infection
Target	IC50: 20.8 nM (RIP3)[1]
In Vitro	HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines[1]. HS-1371 can block RIP3 S227 phosphorylation[1]. HS-1371 rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death[1].
References	[1]. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125.