1818389-84-2

1818389-84-2 structure

Name: SPHINX31
Chemical Name: SPHINX31
CAS Number: 1818389-84-2
Molecular Formula: C₂₇H₂₄F₃N₅O₂
Molecular Weight: 507.51
Catalog: Signaling Pathways Cell Cycle/DNA Damage SRPK
Create Date: 2019-06-01 11:25:31
Modify Date: 2024-01-05 16:21:14
SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), which is a SRPK1 substrate. SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].

Name	SPHINX31

Description	SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), which is a SRPK1 substrate. SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> SRPK
Target	IC50: 5.9 nM (SRPK1)[1].
References	[1]. Batson J, et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832.