Name | (5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione |
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Synonyms |
(5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione
Atis-16-ene-15,20-dione, 18,20-epoxy-7-hydroxy-, (5β,7α,8α,9β,10α,12α)- |
Description | NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association; decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo; inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth. |
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References | References 1. Wang W, et al. Cell Res. 2011 May;21(5):730-40. 2. Yan M, et al. Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197. 3. He X, et al. Cell Discov. 2017 Jan 31;3:17003. View Related Products by Target Beta-catenin |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 549.2±50.0 °C at 760 mmHg |
Molecular Formula | C22H30O4 |
Molecular Weight | 330.418 |
Flash Point | 198.5±23.6 °C |
Exact Mass | 330.183105 |
LogP | 1.41 |
Vapour Pressure | 0.0±3.4 mmHg at 25°C |
Index of Refraction | 1.588 |
Storage condition | 2-8°C |