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1099592-35-4

1099592-35-4 structure
1099592-35-4 structure
  • Name: NSAH
  • Chemical Name: 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone
  • CAS Number: 1099592-35-4
  • Molecular Formula: C18H14N2O3
  • Molecular Weight: 306.315
  • Create Date: 2020-01-11 19:27:05
  • Modify Date: 2024-01-02 11:46:26
  • A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.

Name 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone
Synonyms 2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylene]benzohydrazide
2-Hydroxy-1-naphthaldehyde salicyloylhydrazone
Benzoic acid, 2-hydroxy-, ((2-hydroxy-1-naphthalenyl)methylene)hydrazide
Benzoic acid, 2-hydroxy-, 2-[(1E)-(2-hydroxy-1-naphthalenyl)methylene]hydrazide
2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylidene]benzohydrazide
Description A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.
References References 1. Ahmad MF, et al. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201620220. View Related Products by Target Nucleoside Antimetabolite/Analog
Density 1.3±0.1 g/cm3
Molecular Formula C18H14N2O3
Molecular Weight 306.315
Exact Mass 306.100433
LogP 6.08
Index of Refraction 1.647
Hazard Codes Xi