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  • DC Chemicals Limited
  • China
  • Product Name: YW1128
  • Price: $950.0/100mg $1600.0/250mg $3200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2131223-64-6

2131223-64-6 structure
2131223-64-6 structure
  • Name: YW1128
  • Chemical Name: 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide
  • CAS Number: 2131223-64-6
  • Molecular Formula: C20H17N5O
  • Molecular Weight: 343.382
  • Catalog: Signaling Pathways Stem Cell/Wnt Wnt
  • Create Date: 2020-01-12 09:16:34
  • Modify Date: 2024-01-04 19:43:11
  • YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.

Name 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide
Synonyms 5-Methyl-1-(2-methylphenyl)-N-(2-quinolinyl)-1H-1,2,3-triazole-4-carboxamide
1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-
Description YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.
In Vitro YW1128 is an inhibitor of Wnt/��-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.It decreases protein levels of ��-catenin in the presence of the GSK3�� inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.
Density 1.3±0.1 g/cm3
Molecular Formula C20H17N5O
Molecular Weight 343.382
Exact Mass 343.143311
LogP 3.13
Index of Refraction 1.687