286935-60-2

286935-60-2 structure

Name: Gambogic amide
Chemical Name: gambogic amide
CAS Number: 286935-60-2
Molecular Formula: C₃₈H₄₅NO₇
Molecular Weight: 627.766
Create Date: 2020-01-12 16:37:04
Modify Date: 2024-01-05 07:35:41
A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM; selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs; potently represses cyclin A1 expression and blocks K562 cell proliferation; diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.

Name	gambogic amide
Synonyms	2-Butenamide, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)- gambogic amide (2Z)-4-[(1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9, 11,15-pentaen-19-yl]-2-methyl-2-butenamide

Description	A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM; selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs; potently represses cyclin A1 expression and blocks K562 cell proliferation; diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.
References	References 1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34. 2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36. 3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8. View Related Products by Target Trk Receptor