310460-39-0

310460-39-0 structure

Name: CPYPP
Chemical Name: (4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
CAS Number: 310460-39-0
Molecular Formula: C₁₈H₁₃ClN₂O₂
Molecular Weight: 324.761
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-01-19 21:38:55
Modify Date: 2024-01-14 03:35:15
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.

Name	(4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Synonyms	(4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione 3,5-Pyrazolidinedione, 4-[(2E)-3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-, (4Z)-

Description	CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.
References	References 1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97. 2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7. View Related Products by Target Small GTPase

Hazard Codes	Xi