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  • DC Chemicals Limited
  • China
  • Product Name: MIND4-17
  • Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

345989-24-4

345989-24-4 structure
345989-24-4 structure
  • Name: MIND4-17
  • Chemical Name: MIND4-17
  • CAS Number: 345989-24-4
  • Molecular Formula: C20H15N5O3S
  • Molecular Weight: 405.430
  • Catalog: Signaling Pathways NF-κB Keap1-Nrf2
  • Create Date: 2020-01-12 07:16:50
  • Modify Date: 2024-01-16 19:23:53
  • An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.

Name MIND4-17
Synonyms MIND4-17
5-Nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}pyridine
5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine
Pyridine, 5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-
MFCD01899657
Description An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.
References References 1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. View Related Products by Target Keap1-Nrf2
Density 1.4±0.1 g/cm3
Boiling Point 667.5±65.0 °C at 760 mmHg
Molecular Formula C20H15N5O3S
Molecular Weight 405.430
Flash Point 357.5±34.3 °C
Exact Mass 405.089569
LogP 5.49
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.698