380572-02-1
380572-02-1 structure
- Name: SRPIN-803
- Chemical Name: (6E)-6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
- CAS Number: 380572-02-1
- Molecular Formula: C14H9F3N4O3S
- Molecular Weight: 370.306
- Create Date: 2020-01-12 11:11:49
- Modify Date: 2024-04-03 14:37:12
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SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2; prevents VEGF production more effectively than SRPIN340, topical administration of SRPIN803 suppresses intraocular neovascularization in mouse model.
| Name | (6E)-6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one |
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| Synonyms |
(6E)-6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
7H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-7-one, 5,6-dihydro-6-[(4-hydroxy-3-methoxyphenyl)methylene]-5-imino-2-(trifluoromethyl)-, (6E)- |
| Description | SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2; prevents VEGF production more effectively than SRPIN340, topical administration of SRPIN803 suppresses intraocular neovascularization in mouse model. |
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| References | References 1. Morooka S, et al. Mol Pharmacol. 2015 Aug;88(2):316-25. View Related Products by Target SRPK |
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 428.5±55.0 °C at 760 mmHg |
| Molecular Formula | C14H9F3N4O3S |
| Molecular Weight | 370.306 |
| Flash Point | 212.9±31.5 °C |
| Exact Mass | 370.034760 |
| LogP | 1.60 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.678 |